TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of 50% inactivated mouse Nav1.7 expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs interval...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells at -120 mV holding potential measured for 8 sec by patch-clamp methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 44nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 112nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 129nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 136nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 142nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 215nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 375nMAssay Description:Inhibition of 50% inactivated human Nav1.7alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Antagonist activity at 5HT2B (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at human alpha2B-adrenergic receptorMore data for this Ligand-Target Pair
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at alpha1D-adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 8.00E+3nMAssay Description:Antagonist activity at alpha2A-adrenergic receptor (unknown origin)More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells at -140 mV holding potential measured for 8 secs by patch-clamp methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 2.25E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 2.42E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 2.42E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of 50% inactivated human Nav1.5alpha expressed in HEK293 cells at holding potential of -60 mV incubated for 5 mins measured at 10 secs int...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at human muscarinic M1 receptorMore data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Department Of Discovery Chemistry Merck
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using warfarin as substrate after 30 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair