Compile Data Set for Download or QSAR
maximum 50k data
Found 28 Enz. Inhib. hit(s) with all data for entry = 50003221
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(BIBW2992 | CHEMBL2347958)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(BIBW2992 | CHEMBL2347958)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | CHEMBL2138625 | MP-412)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of human EGFR L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | CHEMBL2138625 | MP-412)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of human EGFR T790M mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | CHEMBL2138625 | MP-412)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | CHEMBL2138625 | MP-412)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of human EGFR T790M mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468247(HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50:  6nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468248(CHEMBL4290869)
Affinity DataIC50:  9.80nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(BIBW2992 | CHEMBL2347958)
Affinity DataIC50:  10nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  11nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50406868(BIBW2992 | CHEMBL2347958)
Affinity DataIC50:  14nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468245(AV-412 | CHEMBL2138625 | MP-412)
Affinity DataIC50:  19nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468248(CHEMBL4290869)
Affinity DataIC50:  19nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human EGFR T790M/L858R mutant expressed in mouse Ba/F3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM4779(CHEMBL31965 | CHEMBL545315 | CI-1033 | Canertinib ...)
Affinity DataIC50:  30nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468248(CHEMBL4290869)
Affinity DataIC50:  33nMAssay Description:Inhibition of EGFR T790M/L858R mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50:  46nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468246(CHEMBL4286374)
Affinity DataIC50:  96nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM50468246(CHEMBL4286374)
Affinity DataIC50:  120nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM246608(4-{4-[6-(4-(4-Bromophenyl)-3-cyano-2-imino)-1,2-di...)
Affinity DataIC50:  1.04E+3nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Ain Shams University

Curated by ChEMBL
LigandPNGBDBM246608(4-{4-[6-(4-(4-Bromophenyl)-3-cyano-2-imino)-1,2-di...)
Affinity DataIC50:  1.94E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed