BindingDB PrimarySearch_ki

Found 22 Enz. Inhib. hit(s) with all data for entry = 50001936

Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)

IC50: 4.40nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human SEM cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Gl...More data for this Ligand-Target Pair

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3D Structure (crystal)

Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)

IC50: 6.70nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-G...More data for this Ligand-Target Pair

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3D Structure (crystal)

Histone deacetylase 6(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)

IC50: 8.5nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC6 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair

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3D Structure (crystal)

Histone deacetylase 1(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)

IC50: 9.40nMAssay Description:Inhibition of C-terminal FLAG-His-tagged full length recombinant human HDAC1 expressed in Sf21 insect cells using RHKK(Ac)AMC as substrate by fluores...More data for this Ligand-Target Pair

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Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)

IC50: 13nMAssay Description:Inhibition of recombinant human HDAC3/NCOR2 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluorescence-based assayMore data for this Ligand-Target Pair

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Histone deacetylase 2(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)

IC50: 27nMAssay Description:Inhibition of C-terminal GST-tagged recombinant human HDAC2 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair

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Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50069989((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)

IC50: 28nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in imatinib-resistant human SUP-B15 cells using Suc-LLVY aminoluciferin as substrate after...More data for this Ligand-Target Pair

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3D Structure (crystal)

Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50450706(CHEMBL4167623)

IC50: 260nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-G...More data for this Ligand-Target Pair

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Histone deacetylase 6(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50450706(CHEMBL4167623)

IC50: 270nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human HDAC6 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair

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Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50450706(CHEMBL4167623)

IC50: 394nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human SEM cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Gl...More data for this Ligand-Target Pair

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Histone deacetylase 8(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50450706(CHEMBL4167623)

IC50: 530nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC8 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair

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Histone deacetylase 8(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)

IC50: 609nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC8 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair

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3D Structure (crystal)

Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50450706(CHEMBL4167623)

IC50: 821nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in imatinib-resistant human SUP-B15 cells using Suc-LLVY aminoluciferin as substrate after...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Histone deacetylase 1(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50450706(CHEMBL4167623)

IC50: 6.90E+3nMAssay Description:Inhibition of C-terminal FLAG-His-tagged full length recombinant human HDAC1 expressed in Sf21 insect cells using RHKK(Ac)AMC as substrate by fluores...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50450706(CHEMBL4167623)

IC50: 1.50E+4nMAssay Description:Inhibition of recombinant human HDAC3/NCOR2 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluorescence-based assayMore data for this Ligand-Target Pair

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Histone deacetylase 2(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50450706(CHEMBL4167623)

IC50: 1.80E+4nMAssay Description:Inhibition of C-terminal GST-tagged recombinant human HDAC2 expressed in baculovirus infected insect cells using RHKK(Ac)AMC as substrate by fluoresc...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)

IC50: >2.50E+4nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human SEM cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Gl...More data for this Ligand-Target Pair

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Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)

IC50: >2.50E+4nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-G...More data for this Ligand-Target Pair

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Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)

IC50: >2.50E+4nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in imatinib-resistant human SUP-B15 cells using Suc-LLVY aminoluciferin as substrate after...More data for this Ligand-Target Pair

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Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)

IC50: >2.50E+4nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human HL60 cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-G...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)

IC50: >2.50E+4nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in human SEM cells using Suc-LLVY aminoluciferin as substrate after 2 hrs by proteasome-Gl...More data for this Ligand-Target Pair

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Proteasome subunit beta type-5(Homo sapiens (Human))
Heinrich Heine University D£Sseldorf

Curated by ChEMBL

PNG

BDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)

IC50: >2.50E+4nMAssay Description:Inhibition of chymotrypsin-like activity of 20S proteasome in imatinib-resistant human SUP-B15 cells using Suc-LLVY aminoluciferin as substrate after...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
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