Compile Data Set for Download or QSAR
maximum 50k data
Found 37 Enz. Inhib. hit(s) with all data for entry = 50008256
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517181(CHEMBL4541628)
Affinity DataIC50:  109nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517187(CHEMBL4464335 | US11053226, Example 1-7)
Affinity DataIC50:  115nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517173(CHEMBL4579956 | US11053226, Example 3-2)
Affinity DataIC50:  139nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517182(CHEMBL4591653 | US11053226, Example 3-1)
Affinity DataIC50:  150nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517180(CHEMBL4457550 | US11053226, Example 82)
Affinity DataIC50:  174nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517187(CHEMBL4464335 | US11053226, Example 1-7)
Affinity DataIC50:  219nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517181(CHEMBL4541628)
Affinity DataIC50:  299nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517179(CHEMBL4520093 | US11053226, Example 13)
Affinity DataIC50:  299nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517189(CHEMBL4573277 | US11053226, Example 41)
Affinity DataIC50:  369nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517173(CHEMBL4579956 | US11053226, Example 3-2)
Affinity DataIC50:  604nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517184(CHEMBL4444447 | US11053226, Example 76)
Affinity DataIC50:  638nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517182(CHEMBL4591653 | US11053226, Example 3-1)
Affinity DataIC50:  683nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517188(CHEMBL4476533 | US11053226, Example 129)
Affinity DataIC50:  1.27E+3nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517186(CHEMBL4570206 | US11053226, Example 109)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517178(CHEMBL4456127 | US11053226, Example 114)
Affinity DataIC50:  1.37E+3nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517179(CHEMBL4520093 | US11053226, Example 13)
Affinity DataIC50:  1.68E+3nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517174(CHEMBL4435858 | US11053226, Example 97)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517185(CHEMBL4466759 | US11053226, Example 118)
Affinity DataIC50:  2.12E+3nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517183(CHEMBL4577812)
Affinity DataIC50:  2.78E+3nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517189(CHEMBL4573277 | US11053226, Example 41)
Affinity DataIC50:  3.55E+3nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517176(CHEMBL4569400 | US11053226, Example 140)
Affinity DataIC50:  4.26E+3nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517177(CHEMBL4522790 | US11053226, Example 155)
Affinity DataIC50:  6.63E+3nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517187(CHEMBL4464335 | US11053226, Example 1-7)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of KRAS G12C mutant in human A549 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EGF ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517183(CHEMBL4577812)
Affinity DataIC50:  1.13E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517184(CHEMBL4444447 | US11053226, Example 76)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517180(CHEMBL4457550 | US11053226, Example 82)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517175(CHEMBL4455193 | US11053226, Example 163)
Affinity DataIC50:  1.42E+4nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517174(CHEMBL4435858 | US11053226, Example 97)
Affinity DataIC50:  1.79E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517186(CHEMBL4570206 | US11053226, Example 109)
Affinity DataIC50:  2.39E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517178(CHEMBL4456127 | US11053226, Example 114)
Affinity DataIC50:  2.80E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517185(CHEMBL4466759 | US11053226, Example 118)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517188(CHEMBL4476533 | US11053226, Example 129)
Affinity DataIC50:  3.65E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517176(CHEMBL4569400 | US11053226, Example 140)
Affinity DataIC50:  4.12E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517177(CHEMBL4522790 | US11053226, Example 155)
Affinity DataIC50:  5.27E+4nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517175(CHEMBL4455193 | US11053226, Example 163)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in EGF-induced ERK1/2 phosphorylation incubated for 4 hrs followed by EG...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517190(CHEMBL4525691 | US11053226, Example 180)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of GDP bound N terminal His-tagged KRAS G12C/C118A mutant (unknown origin) (1 to 169 residues) assessed as reduction in SOS-mediated guani...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGTPase KRas(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50517187(CHEMBL4464335 | US11053226, Example 1-7)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to KRAS (unknown origin) by H-ddNMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed