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Found 30 Enz. Inhib. hit(s) with all data for entry = 50007038
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  2nMAssay Description:Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  3.10nMAssay Description:Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as cell growth inhibition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505629(CHEMBL4436772)
Affinity DataIC50:  5.5nMAssay Description:Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50041086(CHEMBL3355430)
Affinity DataIC50:  9.5nMAssay Description:Displacement of PMDM6-F fluorescent probe from human recombinant His-tagged MDM2 (1 to 118 residues) after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505629(CHEMBL4436772)
Affinity DataIC50: >10nMAssay Description:Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as cell growth inhibition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM112754(US8629141, 21)
Affinity DataIC50: >10nMAssay Description:Binding affinity to cereblon in human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM112754(US8629141, 21)
Affinity DataIC50: >10nMAssay Description:Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as cell growth inhibition measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505629(CHEMBL4436772)
Affinity DataIC50: >10nMAssay Description:Binding affinity to cereblon in human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM112754(US8629141, 21)
Affinity DataIC50: >10nMAssay Description:Binding affinity to cereblon in human MDA-MB-231 cells assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505629(CHEMBL4436772)
Affinity DataIC50: >10nMAssay Description:Binding affinity to cereblon in human MDA-MB-231 cells assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  29nMAssay Description:Binding affinity to cereblon in human MDA-MB-468 cells assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  32nMAssay Description:Binding affinity to cereblon in human MDA-MB-231 cells assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM112754(US8629141, 21)
Affinity DataIC50:  48nMAssay Description:Displacement of PMDM6-F fluorescent probe from human recombinant His-tagged MDM2 (1 to 118 residues) after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  68nMAssay Description:Displacement of PMDM6-F fluorescent probe from human recombinant His-tagged MDM2 (1 to 118 residues) after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  96nMAssay Description:Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as reduction in cell growth inhibition measured after 4 days in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  168nMAssay Description:Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as reduction in cell growth inhibition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  211nMAssay Description:Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as reduction in cell growth inhibition measured after 4 days in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  400nMAssay Description:Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as reduction in cell growth inhibition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  419nMAssay Description:Binding affinity to cereblon in human MDA-MB-468 cells assessed as reduction in cell growth inhibition measured after 4 days in presence of 10 uM len...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  496nMAssay Description:Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as reduction in cell growth inhibition measured after 4 days in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  623nMAssay Description:Binding affinity to cereblon in human MDA-MB-231 cells assessed as reduction in cell growth inhibition measured after 4 days in presence of 10 uM of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  964nMAssay Description:Binding affinity to cereblon in human MDA-MB-468 cells assessed as reduction in cell growth inhibition measured after 4 days in presence of 30 uM len...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  982nMAssay Description:Binding affinity to cereblon in human RV4:11/IRMI-2 cells harboring p53 hotspot mutation Y236H/R249G assessed as reduction in cell growth inhibition ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  1.37E+3nMAssay Description:Binding affinity to cereblon in human MDA-MB-231 cells assessed as reduction in cell growth inhibition measured after 4 days in presence of 30 uM of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM112754(US8629141, 21)
Affinity DataIC50:  1.47E+3nMAssay Description:Binding affinity to cereblon in human RV4:11 cells expressing wild type p53 assessed as cell growth inhibition measured after 4 daysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  2.07E+3nMAssay Description:Binding affinity to cereblon in human MDA-MB-468 cells assessed as reduction in cell growth inhibition measured after 4 days in presence of 100 uM le...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein cereblon(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505628(CHEMBL4449512)
Affinity DataIC50:  2.14E+3nMAssay Description:Binding affinity to cereblon in human MDA-MB-231 cells assessed as reduction in cell growth inhibition measured after 4 days in presence of 100 uM of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505630(CHEMBL4544452)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of PMDM6-F fluorescent probe from human recombinant His-tagged MDM2 (1 to 118 residues) after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505632(CHEMBL4446816)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of PMDM6-F fluorescent probe from human recombinant His-tagged MDM2 (1 to 118 residues) after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50505631(CHEMBL4527016)
Affinity DataIC50: >2.00E+4nMAssay Description:Displacement of PMDM6-F fluorescent probe from human recombinant His-tagged MDM2 (1 to 118 residues) after 15 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed