Compile Data Set for Download or QSAR
maximum 50k data
Found 4 Enz. Inhib. hit(s) with all data for entry = 8944
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  80nMAssay Description:Calu-3 2B4 cells were adsorbed with MOI 0.1 PFU/cell of SARS-CoV-2 (2019-nCoV/USA-WA1/2020 strain) at 37°C. Plates were manually rocked every 10 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  90nMAssay Description:Calu-3 2B4 cells were adsorbed with MOI 0.1 PFU/cell of SARS-CoV-2 (2019-nCoV/USA-WA1/2020 strain) at 37°C. Plates were manually rocked every 10 min ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrf1a protein(MERS-CoV)
University Of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  150nMAssay Description:At 48 hours prior to infection, Calu-3 2B4 cells were plated in a 96-well black-walled clear bottom plate at 5x104 cells/well. A 10 mM stock of NHC w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of North Carolina At Chapel Hill

LigandPNGBDBM430624(Beta-D-N4-hydroxycytidine | EIDD-1931 | N(4)-Hydro...)
Affinity DataIC50:  300nMAssay Description:Vero E6 cells were plated at 20,000 cells/well in a 96-well plate. 24hr later, medium containing a dose response of NHC was added concurrent with SAR...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed