Compile Data Set for Download or QSAR
maximum 50k data
Found 66 Enz. Inhib. hit(s) with all data for entry = 7568
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202632(US9242943, 41)
Affinity DataIC50:  10nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202636(US9242943, 45)
Affinity DataIC50:  17nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202615(US9242943, 24)
Affinity DataIC50:  18nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202619(US9242943, 28)
Affinity DataIC50:  44nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202617(US9242943, 26)
Affinity DataIC50:  77nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202626(US9242943, 35)
Affinity DataIC50:  100nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202628(US9242943, 37)
Affinity DataIC50:  120nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202606(US9242943, 15)
Affinity DataIC50:  120nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202612(US9242943, 21)
Affinity DataIC50:  130nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202617(US9242943, 26)
Affinity DataIC50:  160nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202606(US9242943, 15)
Affinity DataIC50:  170nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202630(US9242943, 39)
Affinity DataIC50:  180nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202615(US9242943, 24)
Affinity DataIC50:  250nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202627(US9242943, 36)
Affinity DataIC50:  250nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202605(US9242943, 14)
Affinity DataIC50:  260nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202620(US9242943, 29)
Affinity DataIC50:  270nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202612(US9242943, 21)
Affinity DataIC50:  279nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202637(US9242943, 46)
Affinity DataIC50:  300nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202604(US9242943, 13)
Affinity DataIC50:  310nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202631(US9242943, 40)
Affinity DataIC50:  320nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202609(US9242943, 18)
Affinity DataIC50:  320nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202596(US9242943, 5)
Affinity DataIC50:  340nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202600(US9242943, 9)
Affinity DataIC50:  350nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202601(US9242943, 10)
Affinity DataIC50:  410nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202593(US9242943, 2)
Affinity DataIC50:  450nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202618(US9242943, 27)
Affinity DataIC50:  558nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202624(US9242943, 33)
Affinity DataIC50:  580nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202597(US9242943, 6)
Affinity DataIC50:  605nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202611(US9242943, 20)
Affinity DataIC50:  610nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202618(US9242943, 27)
Affinity DataIC50:  660nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202626(US9242943, 35)
Affinity DataIC50:  732nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202635(US9242943, 44)
Affinity DataIC50:  890nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202625(US9242943, 34)
Affinity DataIC50:  1.04E+3nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202603(US9242943, 12)
Affinity DataIC50:  1.09E+3nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202631(US9242943, 40)
Affinity DataIC50:  1.10E+3nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202613(US9242943, 22)
Affinity DataIC50:  1.11E+3nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202605(US9242943, 14)
Affinity DataIC50:  1.17E+3nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202624(US9242943, 33)
Affinity DataIC50:  1.21E+3nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202610(US9242943, 19)
Affinity DataIC50:  1.21E+3nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202597(US9242943, 6)
Affinity DataIC50:  1.36E+3nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202625(US9242943, 34)
Affinity DataIC50:  1.48E+3nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202614(US9242943, 23)
Affinity DataIC50:  1.66E+3nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202625(US9242943, 34)
Affinity DataIC50:  2.00E+3nMT: 2°CAssay Description:Inhibition of cytochromes P450 (CYPs) 2C9, 2D6 and 3A4 was assessed using human liver microsomes and CYP-selective substrate metabolism reactions. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202632(US9242943, 41)
Affinity DataIC50:  2.14E+3nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202599(US9242943, 8)
Affinity DataIC50:  2.19E+3nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202611(US9242943, 20)
Affinity DataIC50:  2.27E+3nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202620(US9242943, 29)
Affinity DataIC50:  2.30E+3nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202623(US9242943, 32)
Affinity DataIC50:  2.36E+3nMAssay Description:DNA of the human APP wt gene (APP695) were used to assess the potency of the compounds in a cellular assay. The cells were seeded in 96-well microtit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202613(US9242943, 22)
Affinity DataIC50:  2.43E+3nMAssay Description:The assay uses the principle of inhibition of human TMEM27 cleavage by endogenous cellular BACE2 in the Ins1e rat cell line and shedding from the cel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Siena Biotech

US Patent
LigandPNGBDBM202627(US9242943, 36)
Affinity DataIC50:  2.60E+3nMpH: 5.5 T: 2°CAssay Description:A substrate peptide is labeled at the N-terminus with tryptophan and at the C-terminus with the fluorophore MR121 (for cathepsin D the 10 amino acid ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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