Reaction Details Report a problem with these data
Cell Reactant:
Estrogen-Related Receptor, alpha Mutant (C325S)
Syringe Reactant:
BDBM22421
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
05/29/08
pH:
7.5±n/a
Temperature:
298.15±n/a (K)
ΔHobs :
-54.34±n/a (kJ/mole)
Corrected for ΔHioniz:
no
ΔS° :
-0.0659±n/a (kJ/mole-K)
Citation
Kallen, J; Lattmann, R; Beerli, R; Blechschmidt, A; Blommers, MJ; Geiser, M; Ottl, J; Schlaeppi, JM; Strauss, A; Fournier, B Crystal structure of human estrogen-related receptor alpha in complex with a synthetic inverse agonist reveals its novel molecular mechanism. J Biol Chem 282:23231-9 (2007) [PubMed] Article
Cell React
Source:
Recombinant ERR alpha mutant ligand-binding domain was cloned and expressed in sf9 insect cells.
Purity:
The purification of the frozen Sf9 cell pellets was done by three-step chromatography. SDS-PAGE analysis revealed good and soluble expression of ERR apha LBD.
Name:
Estrogen-Related Receptor, alpha Mutant (C325S)
Synonyms:
ERR-alpha | Nuclear receptor subfamily 3 group B member 1 | Steroid hormone receptor ERR1
Type:
Ligand Binding Domain
Mol. Mass.:
25035.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
230
Sequence:
VNALVSHLLVVEPEKLYAMPDPAGPDGHLPAVATLSDLFDREIVVTISWAKSIPGFSSLSLSDQMSVLQSVWMEVLVLGVAQRSLPLQDELAFAEDLVLDEEGARAAGLGELGAALLQLVRRLQALRLEREEYVLLKALALANSDSVHIEDAEAVEQLREALHEALLEYEAGRAGPGGGAERRRAGRLLLTLPLLRQTAGKVLAHFYGVKLEGKVPMHKLFLEMLEAMMD