Reaction Details  Report a problem with these data
Cell Reactant:
XIAP-BIR3
Syringe Reactant:
BDBM26201
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
12/17/08
pH:
7.4±n/a
Temperature:
298.15±n/a (K)
Corrected for ΔHioniz:
no
Citation
 Cywin, CL; Huang, JW; Klunder, JM; Zhang, Z; Hoermann, M; Wu, B; Brickwood, JR; Cellitti, JF; David, E; Zhang, X; Grob, PM; Dahl, R; Schwartz, R; Shiau, CW; Welsh, K; Pauletti, D; Emdadi, A; Barringer, KJ; Stebbins, JL; Shih, CK; Sorge, CL; Reed, JC; Erickson, DA; Pellecchia, M; Joseph, DP; Hattox, SE Fragment-based design of small molecule X-linked inhibitor of apoptosis protein inhibitors. J Med Chem 51:7111-8 (2008) [PubMed]  Article
Cell React
Source:
The protein was expressed in the Escherichia coli strain BL21(DE3).
Prep. Method:
The protein was purified using Ni2+ affinity chromatography.
Name:
E3 ubiquitin-protein ligase XIAP [241-356]
Synonyms:
API3 | BIR3 domain of X-linked inhibitor of apoptosis protein | BIRC4 | E3 ubiquitin-protein ligase (XIAP-BIR3) | E3 ubiquitin-protein ligase XIAP BIR-3 | E3 ubiquitin-protein ligase XIAP BIR3 | IAP3 | X chromosome-linked inhibitor of apoptosis BIR3 domain (XIAP BIR3) | X-linked inhibitor of apoptosis protein BIR3 domain (XIAP BIR-3) | XIAP | XIAP-BIR3 | XIAP_HUMAN | baculovirus IAP repeat 3 (BIR3) domain of XIAP
Type:
Protein Binding Domain
Mol. Mass.:
13276.62
Organism:
Homo sapiens (Human)
Description:
BIR3 of XIAP: RESIDUES 241-356.
Residue:
116
Sequence:
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
  
Syringe React
Name:
BDBM26201
Synonyms:
(2S)-2-{[(2S)-1-[(2S)-2-[(2S)-2-aminopropanamido]-3-methylbutanoyl]pyrrolidin-2-yl]formamido}-4-methylhexanoic acid | AVPI
Type:
4-mer
Emp. Form.:
C20H36N4O5
Mol. Mass.:
412.5236
SMILES:
CCC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)C(O)=O |r|
Structure:
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