Cell Reactant:
Purine nucleoside phosphorylase
Syringe Reactant:
BDBM50293064
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
03/18/13
ΔG°:
-52.8±1 (kJ/mole)
pH:
7.4±0
Temperature:
298.15±0 (K)
Citation
 Edwards, AAMason, JMClinch, KTyler, PCEvans, GBSchramm, VL Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase. Biochemistry 48:5226-38 (2009) [PubMed]  Article
Cell React
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Syringe React
Name:
BDBM50293064
Synonyms:
7-({[1,3-Dihydroxy-2-(hydroxymethyl)propan-2-yl]amino}methyl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one | CHEMBL523107 | Immucillins, 10
Type:
Small organic molecule
Emp. Form.:
C11H16N4O4
Mol. Mass.:
268.2691
SMILES:
OCC(CO)(CO)NCc1c[nH]c2c1nc[nH]c2=O
Structure:
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