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Cell Reactant:MAP kinase ERK1
Syringe Reactant:BDBM103302
Meas. Tech.:Enzyme Inhibition
Entry Date:10/22/14
 
ΔG°:-36.8± (kJ/mole)
pH:7.5±0
Log10Kb:6.66± n/a
Temperature:288.15±0 (K)
ΔH° :-86.2±0.800 (kJ/mole)
ΔHobs:n/a
Ionic Strength:n/a
Corrected for ΔHioniz:n/a
Protons Released:n/a
ΔCp :n/a
Stoich. Param.:n/a
ΔS° : -0.1716±0 (kJ/mole-K)
Comments:n/a
 
Citation Chaikuad, ATacconi, EMZimmer, JLiang, YGray, NSTarsounas, MKnapp, S A unique inhibitor binding site in ER K1/2 is associated with slow binding kinetics Nat Chem Biol10:853-860 (2014) [PubMed]  Article
More Info.:  Get all data from this article ,  ITC RUN data
 
MAP kinase ERK1
Source:n/a
Purity:n/a
Prep. Method:n/a
Name:MAP kinase ERK1
Synonyms:ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | Mitogen-activated protein kinase
Type:Protein
Mol. Mass.:43136.58
Organism:Homo sapiens (Human)
Description:curated by PDB 4QTB
Residue:379
Sequence:
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAY
DHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI
VQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDL
KICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS
NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSD
SKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERL
KELIFQETARFQPGVLEAP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM103302
Source:n/a
Purity:n/a
Prep. Method:n/a
NameBDBM103302
Synonyms:SCH772984 | US8546404, 6
TypeSmall organic molecule
Emp. Form.C33H33N9O2
Mol. Mass.587.6742
SMILESO=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r|
Structure

   
    

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Last update November 1, 2007
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