Reaction Details  Report a problem with these data
Cell Reactant:
C-terminal-binding protein 1 (CtBP1)
Syringe Reactant:
BDBM154571
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
10/15/15
ΔG°:
-3.83±0 (kcal/mole)
pH:
7.5±0
Temperature:
293.15±0 (K)
ΔH° :
-11.32±0.84 (kJ/mole)
ΔS° :
-0.03±0 (kJ/mole-K)
Citation
 Hilbert, BJ; Morris, BL; Ellis, KC; Paulsen, JL; Schiffer, CA; Grossman, SR; Royer, WE Structure-guided design of a high affinity inhibitor to human CtBP. ACS Chem Biol 10:1118-27 (2015) [PubMed]  Article 
Cell React
Name:
C-terminal-binding protein 1
Synonyms:
C-terminal binding protein (CtBP1) | C-terminal-binding protein 1 (CtBP1) | CTBP | CTBP1 | CTBP1_HUMAN
Type:
Protein
Mol. Mass.:
47537.80
Organism:
Homo sapiens (Human)
Description:
Q13363
Residue:
440
Sequence:
MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHASDQL
  
Syringe React
Name:
BDBM154571
Synonyms:
4-Methylthio 2-oxobutyric acid (MTOB)
Type:
Small organic molecule
Emp. Form.:
C5H8O3S
Mol. Mass.:
148.18
SMILES:
CSCCC(=O)C(O)=O
Structure:
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