Cell Reactant:
3-phosphoinositide dependent protein kinase-1
Syringe Reactant:
BDBM50433916
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
11/02/16
ΔG°:
-8.38±n/a (kcal/mole)
Log10Kb:
4.3
Temperature:
310±0 (K)
ΔH° :
-1.2±0.07 (kJ/mole)
ΔS° :
0.02±0 (kJ/mole-K)
Citation
 Schulze, JOSaladino, GBusschots, KNeimanis, SSüß, EOdadzic, DZeuzem, SHindie, VHerbrand, AKLisa, MNAlzari, PMGervasio, FLBiondi, RM Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase. Cell Chem Biol 23:1193-1205 (2016) [PubMed]  Article 
Cell React
Name:
3-phosphoinositide-dependent protein kinase 1
Synonyms:
3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide dependent protein kinase-1 | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (PDK) | 3-phosphoinositide-dependent protein kinase 1 (PDK-1) | 3-phosphoinositide-dependent protein kinase 1 (PDK1)(Δ1-50) | Isoform 2 of 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | Phosphoinositide-dependent protein kinase 1 (PDK1) | Pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) | hPDK1
Type:
Enzyme
Mol. Mass.:
63157.65
Organism:
Homo sapiens (Human)
Description:
O15530
Residue:
556
Sequence:
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRTQTESSTPPGIPGGSRQGPAMDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLSASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ
  
Syringe React
Name:
BDBM50433916
Synonyms:
PS653 ('1,6-dihydrodibenzo[c,d,g]indazol-6-one) | SP-600125
Type:
Small organic molecule
Emp. Form.:
C14H8N2O
Mol. Mass.:
220.2261
SMILES:
O=C1c2ccccc2-c2[nH]nc3cccc1c23
Structure:
Search PDB for entries with ligand similarity: