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Cell Reactant:Gcn5-related N-acetyltransferases (GNAT) superfamily protein PA4794 (PA4794)
Syringe Reactant:BDBM50335523
Meas. Tech.:Enzyme Inhibition
Entry Date:02/21/17
 
ΔG°:-31.2± (kJ/mole)
pH:7.5±0
Log10Kb:5.46± n/a
Temperature:298.15±0 (K)
ΔH° :-36.5±0.350 (kJ/mole)
ΔHobs:n/a
Ionic Strength:n/a
Corrected for ΔHioniz:n/a
Protons Released:n/a
ΔCp :n/a
Stoich. Param.:n/a
ΔS° : -0.0178±0 (kJ/mole-K)
Comments:n/a
 
Citation Majorek, KAKuhn, MLChruszcz, MAnderson, WFMinor, W Structural, functional, and inhibition studies of a Gcn5-related N-acetyltransferase (GNAT) superfamily protein PA4794: a new C-terminal lysine protein acetyltransferase from pseudomonas aeruginosa. J Biol Chem288:30223-35 (2013) [PubMed]  Article
More Info.:  Get all data from this article ,  ITC RUN data ,  Solution Info
 
Gcn5-related N-acetyltransferases (GNAT) superfamily protein PA4794 (PA4794)
Source:n/a
Purity:n/a
Prep. Method:n/a
Name:Gcn5-related N-acetyltransferases (GNAT) superfamily protein PA4794 (PA4794)
Synonyms:n/a
Type:Protein
Mol. Mass.:17787.24
Organism:Pseudomonas aeruginosa
Description:Q9HV14
Residue:160
Sequence:
MQLSHRPAETGDLETVAGFPQDRDELFYCYPKAIWPFSVAQLAAAIAERRGSTVAVHDGQ
VLGFANFYQWQHGDFCALGNMMVAPAARGLGVARYLIGVMENLAREQYKARLMKISCFNA
NAAGLLLYTQLGYQPRAIAERHDPDGRRVALIQMDKPLEP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50335523
Source:n/a
Purity:n/a
Prep. Method:n/a
NameBDBM50335523
Synonyms:(6R,7R)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6R,7R)-3-Acetoxymethyl-7-[2-(2-amino-thiazol-4-yl)-2-hydroxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6R,7R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(E)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6R,7R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6R,7R,E)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6R,7R,Z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6R,7R,Z)-3-(acetoxymethyl)-7-(2-(5-aminothiophen-3-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6R,7S,Z)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (6S,7S,E)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (Cefotaxime)3-Acetoxymethyl-7-[2-(2-amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | (R)-3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(E)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 3-Acetoxymethyl-7-[2-(2-amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-5,8-dioxo-5lambda*4*-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 3-Acetoxymethyl-7-[2-(2-amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 3-Acetoxymethyl-7-[2-(2-amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Cefotaxime) | 3-Acetoxymethyl-7-[2-(2-amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid anion | 3-Acetoxymethyl-7-[2-(2-amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid(Cefotaxime) | 3-Acetoxymethyl-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-methoxyimino]-acetylamino}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid anion | CHEMBL102 | Cefotax | Claforan | Kefotex | cefotaxim | cefotaxime
TypeSmall organic molecule
Emp. Form.C16H17N5O7S2
Mol. Mass.455.465
SMILESCO\N=C(\C(=O)N[C@H]1[C@H]2SCC(COC(C)=O)=C(N2C1=O)C(O)=O)c1csc(N)n1 |r,c:16|
Structure

   
    

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