Cell Reactant:
Methylthioadenosine Phosphorylase (MTAP)
Syringe Reactant:
BDBM218800
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
03/22/17
ΔG°:
-35.1±n/a (kJ/mole)
pH:
7.4±0
Log10Kb:
-?
Temperature:
319.15±0 (K)
Citation
 Firestone, RSCameron, SAKarp, JMArcus, VLSchramm, VL Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase. ACS Chem Biol 12:464-473 (2017) [PubMed]  Article
Cell React
Name:
S-methyl-5'-thioadenosine phosphorylase
Synonyms:
5'-Methylthioadenosine phosphorylase (MTAP) | MTA phosphorylase | MTAPase | Methylthioadenosine Phosphorylase (MTAP) | S-methyl-5 -thioadenosine phosphorylase
Type:
Enzyme
Mol. Mass.:
31239.23
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
283
Sequence:
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH
  
Syringe React
Name:
BDBM218800
Synonyms:
MT-Tubercidin
Type:
Small organic molecule
Emp. Form.:
C12H16N4O3S
Mol. Mass.:
296.345
SMILES:
CSCC1OC([C@@H](O)[C@H]1O)n1ccc2c(N)ncnc12 |r|
Structure:
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