Cell Reactant:
Ephrin type-A receptor 3 ligand binding domain (EphA3-LBD)
Syringe Reactant:
BDBM223311
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
04/27/17
ΔG°:
-30.55±n/a (kJ/mole)
pH:
6.5±0
Temperature:
300.15±0 (K)
ΔH° :
-6.45±1.3 (kJ/mole)
ΔS° :
0.0803±0 (kJ/mole-K)
Citation
 Wu, BDe, SKKulinich, ASalem, AFKoeppen, JWang, RBarile, EWang, SZhang, DEthell, IPellecchia, M Potent and Selective EphA4 Agonists for the Treatment of ALS. Cell Chem Biol 24:293-305 (2017) [PubMed]  Article 
Cell React
Name:
Ephrin type-A receptor 3 [29-207]
Synonyms:
EPHA3 | EPHA3_HUMAN | ETK | ETK1 | Ephrin type-A receptor 3 ligand binding domain (EphA3-LBD) | HEK | TYRO4
Type:
Protein
Mol. Mass.:
20707.76
Organism:
Homo sapiens (Human)
Description:
Human EphA3-LBD (29-207 aa)
Residue:
179
Sequence:
EVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDHSQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLGTCKETFNLYYMESDDDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVGPVNKKGFYLAFQDVGACVALVSVRVYFKKCPFTVK
  
Syringe React
Name:
BDBM223311
Synonyms:
123C4
Type:
Small organic molecule
Emp. Form.:
C43H47ClN8O6
Mol. Mass.:
807.336
SMILES:
COc1ccc2[nH]cc(CCNC(=O)[C@H](Cc3ccncc3)NC(=O)[C@H](Cc3ccc(Cl)cc3)NC(=O)[C@H](Cc3c[nH]c4ccc(O)cc34)NC(=O)CCCN)c2c1 |r|
Structure:
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