Reaction Details  Report a problem with these data
Cell Reactant:
Phospholipase C-γ1 SH2 domain (PLCC)
Syringe Reactant:
BDBM225242
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
05/11/17
ΔG°:
-12.09±n/a (kcal/mole)
pH:
7.4±0
Log10Kb:
7.2
Temperature:
298.15±0 (K)
ΔH° :
-6.7±0.38 (kJ/mole)
ΔS° :
0±0 (kJ/mole-K)
Citation
 McKercher, MA; Guan, X; Tan, Z; Wuttke, DS Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-¿1 Protein. Biochemistry 56:2225-2237 (2017) [PubMed]  Article
Cell React
Name:
Phospholipase C-γ1 SH2 domain (PLCC)
Synonyms:
PLC1 | PLCG1 | PLCG1_HUMAN
Type:
Protein
Mol. Mass.:
11560.59
Organism:
Homo sapiens (Human)
Description:
Human phospholipase C-γ1 C-terminal SH2 domain (663-759 aa)
Residue:
97
Sequence:
HESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEE
  
Syringe React
Name:
BDBM225242
Synonyms:
2-Methoxy-N-(2-phenylbenzo[d]oxazol-6-yl)benzenesulfonamide (3) | ErbB2-pep
Type:
Small organic molecule
Emp. Form.:
C66H85N14O25P
Mol. Mass.:
1505.4337
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(O)=O |r|
Structure:
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