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Cell Reactant:Phospholipase C-γ1 SH2 domain (PLCC)
Syringe Reactant:BDBM225245
Meas. Tech.:Enzyme Inhibition
Entry Date:05/11/17
 
ΔG°:-44.0± (kJ/mole)
pH:7.4±0
Log10Kb:7.72± 7.12
Temperature:298.15±0 (K)
ΔH° :-4.17±0.925 (kJ/mole)
ΔHobs:n/a
Ionic Strength:n/a
Corrected for ΔHioniz:n/a
Protons Released:n/a
ΔCp :n/a
Stoich. Param.:n/a
ΔS° : 0.0775±0.00540 (kJ/mole-K)
Comments:n/a
 
Citation McKercher, MAGuan, XTan, ZWuttke, DS Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of Phospholipase C-1 Protein. Biochemistry56:2225-2237 (2017) [PubMed]  Article
More Info.:  Get all data from this article ,  ITC RUN data
 
Phospholipase C-γ1 SH2 domain (PLCC)
Source:n/a
Purity:n/a
Prep. Method:n/a
Name:Phospholipase C-γ1 SH2 domain (PLCC)
Synonyms:n/a
Type:Protein
Mol. Mass.:11560.59
Organism:Homo sapiens (Human)
Description:Human phospholipase C-γ1 C-terminal SH2 domain (663-759 aa)
Residue:97
Sequence:
HESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKIKHCRVQQEGQ
TVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM225245
Source:n/a
Purity:n/a
Prep. Method:n/a
NameBDBM225245
Synonyms:4-Fluoro-N-(2-phenylbenzo[d]oxazol-6-yl)benzenesulfonamide (6) | IRS2-pep
TypeSmall organic molecule
Emp. Form.C56H76N11O22PS2
Mol. Mass.1350.367
SMILESCSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)CN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(O)=O |r|
Structure

   
    

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