Cell Reactant:
Na+/H+ exchanger regulatory factor-1 PDZ domain (PDZ2)
Syringe Reactant:
BDBM228843
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
05/30/17
ΔG°:
-24±2 (kJ/mole)
pH:
8±0
Log10Kb:
6.4
Temperature:
298.15±0 (K)
ΔH° :
-30±2 (kJ/mole)
ΔS° :
-0.02±0.003 (kJ/mole-K)
Citation
 Mamonova, TZhang, QChandra, MCollins, BMSarfo, EBu, ZXiao, KBisello, AFriedman, PA Origins of PDZ Binding Specificity. A Computational and Experimental Study Using NHERF1 and the Parathyroid Hormone Receptor. Biochemistry 56:2584-2593 (2017) [PubMed]  Article 
Cell React
Name:
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [133-300]
Synonyms:
NHERF | NHERF1 | NHRF1_HUMAN | Na+/H+ exchanger regulatory factor-1 PDZ domain (PDZ2) | SLC9A3R1
Type:
Protein
Mol. Mass.:
18472.23
Organism:
Homo sapiens (Human)
Description:
PDZ2 domain of human NHERF1 (133-300 aa)
Residue:
168
Sequence:
NENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQ
  
Syringe React
Name:
BDBM228843
Synonyms:
PTHRct-8 mutant (QAAWETVM) | QAAWETVM
Type:
Small organic molecule
Emp. Form.:
C41H62N10O13S
Mol. Mass.:
935.055
SMILES:
CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)O)C(C)C)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: