Target

Ligand

Substrate

Meas. Tech.

Enzyme Inhibition Assay

pH

6.5±n/a

Temperature

303.15±n/a K

Citation

 Seefeld, MA; Miller, WH; Newlander, KA; Burgess, WJ; DeWolf, WE; Elkins, PA; Head, MS; Jakas, DR; Janson, CA; Keller, PM; Manley, PJ; Moore, TD; Payne, DJ; Pearson, S; Polizzi, BJ; Qiu, X; Rittenhouse, SF; Uzinskas, IN; Wallis, NG; Huffman, WF Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK. J Med Chem 46:1627-35 (2003) [PubMed]  Article Copy BDB DOI

More Info.:

Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method

Name:

Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI

Synonyms:

Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase

Type:

Enzyme

Mol. Mass.:

27989.00

Organism:

Staphylococcus aureus

Description:

Q6GI75

Residue:

256

Sequence:

MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK

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Blast E-value cutoff:

Name:

BDBM8726

Synonyms:

5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35

Type:

Small organic molecule

Emp. Form.:

C12H7Cl3O2

Mol. Mass.:

289.542

SMILES:

Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl

Structure:

Search PDB for entries with ligand similarity:

Similarity to this molecule at least:

Name:

Crotonoyl-ACP

Synonyms:

n/a

Type:

Other Protein Type

Mol. Mass.:

358.43

Organism:

n/a

Description:

1. NAD(P)H is its co-substrate. 2. Crotonoyl-ACP was synthesized using ACP synthase to catalyse the addition of a crotonoyl group from crotonoyl-CoA to apo-ACP

Residue:

3

Sequence:

NA