Target
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ligand
BDBM309205
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
<10.00±n/a nM
Citation
 Amberg, WPohlki, FLange, UWang, YXZhao, HHLi, HBrewer, JTZanze, IDietrich, JVasudevan, ADjuric, SWLao, YHutchins, CW Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent  US9656955 Publication Date 5/23/2017 
Target
Name:
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:
GGNT1 | GLCT1 | GLYT1 | GNT-I | GlcNAc-T I | MGAT | MGAT1 | MGAT1_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
Type:
PROTEIN
Mol. Mass.:
50891.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107587
Residue:
445
Sequence:
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSAWNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN
  
Inhibitor
Name:
BDBM309205
Synonyms:
6-(4-fluorophenyl)-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]pyrrolidin-3-yl}pyrimidin-4-amine | US9656955, Example 728
Type:
Small Organic Molecule
Emp. Form.:
C24H22F2N6O2S
Mol. Mass.:
496.532
SMILES:
Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(ncn2)-c2ccc(F)cc2)[C@H](C1)c1ccc(F)cc1
Structure:
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