Target
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Ligand
BDBM309282
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
<10.00±n/a nM
Citation
 Amberg, WPohlki, FLange, UWang, YXZhao, HHLi, HBrewer, JTZanze, IDietrich, JVasudevan, ADjuric, SWLao, YHutchins, CW Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy US Patent  US9656955 Publication Date 5/23/2017 
Target
Name:
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
Synonyms:
GGNT1 | GLCT1 | GLYT1 | GNT-I | GlcNAc-T I | MGAT | MGAT1 | MGAT1_HUMAN | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
Type:
PROTEIN
Mol. Mass.:
50891.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107587
Residue:
445
Sequence:
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSAWNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN
  
Inhibitor
Name:
BDBM309282
Synonyms:
5-chloro-N-{(3R,4S)-4-(4-fluorophenyl)-1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]pyrrolidin-3-yl}-4-(2,2,2-trifluoroethoxy)pyridin-2-amine | US9656955, Example 806
Type:
Small Organic Molecule
Emp. Form.:
C21H20ClF4N5O3S
Mol. Mass.:
533.927
SMILES:
Cn1cnc(c1)S(=O)(=O)N1C[C@H](Nc2cc(OCC(F)(F)F)c(Cl)cn2)[C@H](C1)c1ccc(F)cc1
Structure:
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