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Target
Dimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L]
Ligand
BDBM517
Substrate
HIV Protease Peptide Substrate
Meas. Tech.
Protease Inhibition Assay
IC50
61±n/a nM
Citation
 Kim, RM; Rouse, EA; Chapman, KT; Schleif, WA; Olsen, DB; Stahlhut, M; Rutkowski, CA; Emini, EA; Tata, JR P1' oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1. Bioorg Med Chem Lett 14:4651-4 (2004) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L]
Synonyms:
HIV-1 Protease Mutant (L10I/M36I/N37D/M46I/R57K/L63P/A71V/G73S/I84V/L90M/I93L) | HIV-1 Protease Mutant V-18C
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L]
Synonyms:
HIV-1 Protease Mutant V-18C Chain A | HIV-1 Protease Mutant V-18C Chain B | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10805.20
Organism:
Human immunodeficiency virus type 1
Description:
L10I/M36I/N37D/M46I/R57K/L63P/A71V/G73S/I84V/L90M/I93L
Residue:
99
Sequence:
PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFIKVKQYDQIPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF
  
Component 2
Name:
Gag-Pol polyprotein [489-587,Q496K,L499I,M525I,N526D,M535I,R546K,L552P,A560V,G562S,I573V,L579M,I582L]
Synonyms:
HIV-1 Protease Mutant V-18C Chain A | HIV-1 Protease Mutant V-18C Chain B | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10805.20
Organism:
Human immunodeficiency virus type 1
Description:
L10I/M36I/N37D/M46I/R57K/L63P/A71V/G73S/I84V/L90M/I93L
Residue:
99
Sequence:
PQITLWKRPIVTIKIGGQLKEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFIKVKQYDQIPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF
  
Inhibitor
Name:
BDBM517
Synonyms:
(2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]carbamoyl}butyl]-N-tert-butyl-4-(pyridin-3-ylmethyl)piperazine-2-carboxamide | CHEMBL115 | Crixivan | INDINAVIR SULFATE | Indinavir | Indinavir, 19 | L-735, 524 | MK639
Type:
Small organic molecule
Emp. Form.:
C36H47N5O4
Mol. Mass.:
613.7895
SMILES:
CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12 |@:19,@@:9|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
HIV Protease Peptide Substrate
Synonyms:
HIV Protease Substrate
Type:
Peptide
Mol. Mass.:
2715.95
Organism:
n/a
Description:
n/a
Residue:
25
Sequence:
VSQNETANAPHTHYLALANINEPIV