Reaction Details Report a problem with these data
Target
Carbonic anhydrase 1
Ligand
BDBM39351
Substrate
n/a
Meas. Tech.
Known Inhibitors of Carbonic Anhydrase
IC50
460±n/a nM
Citation
 Collier, GR; Walder, KR; Campbell, JA; Molero-Navajas, J; Konstantopoulos, N; Krippner, GY Insulin sensitisers and methods of treatment US Patent  US10172837 Publication Date 1/8/2019 
Target
Name:
Carbonic anhydrase 1
Synonyms:
CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA
Type:
Enzyme
Mol. Mass.:
28873.37
Organism:
Homo sapiens (Human)
Description:
P00915
Residue:
261
Sequence:
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
  
Inhibitor
Name:
BDBM39351
Synonyms:
CHLOROTHIAZIDE | MLS000028398 | SMR000058429 | US10172837, Chlorothiazide | cid_2720
Type:
Small organic molecule
Emp. Form.:
C7H6ClN3O4S2
Mol. Mass.:
295.723
SMILES:
NS(=O)(=O)c1cc2c(cc1Cl)N=CNS2(=O)=O |c:12|
Structure:
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