Target
Amine oxidase [flavin-containing] B [I199F]
Ligand
BDBM11022
Substrate
BDBM10999
Meas. Tech.
MAO Inhibition Assay
Ki
500±n/a nM
Citation
 Hubalek, FBinda, CKhalil, ALi, MMattevi, ACastagnoli, NEdmondson, DE Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem 280:15761-6 (2005) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B [I199F]
Synonyms:
AOFB_HUMAN | Amine oxidase (flavin-containing) B | MAOB | Monoamine Oxidase Type B (MAO-B) Mutant (I199F)
Type:
Enzyme
Mol. Mass.:
58802.78
Organism:
Homo sapiens (Human)
Description:
Human recombinant MAO B were expressed and purified from Pichia pastoris.
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIFSTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM11022
Synonyms:
2,3-dihydro-1H-indole-2,3-dione | CHEMBL326294 | Isatin | Isatin (Compound 1)
Type:
Small organic molecule
Emp. Form.:
C8H5NO2
Mol. Mass.:
147.1308
SMILES:
O=C1Nc2ccccc2C1=O
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10999
Synonyms:
Benzenemethanamine | Bn-NH2 | CHEMBL522 | benzylamine | phenylmethanamine
Type:
Small organic molecule
Emp. Form.:
C7H9N
Mol. Mass.:
107.1531
SMILES:
NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: