Target
Retinoid isomerohydrolase
Ligand
BDBM323477
Substrate
n/a
Meas. Tech.
In Vitro Isomerase Inhibition Assay
IC50
55.0±n/a nM
Citation
 Scott, ILKuksa, VAOrme, MWLittle, Jr., TLGall, AHong, F Alkoxy compounds for disease treatment US Patent  US10188615 Publication Date 1/29/2019 
Target
Name:
Retinoid isomerohydrolase
Synonyms:
Lutein isomerase | Meso-zeaxanthin isomerase | RPE65 | RPE65_HUMAN | Retinal pigment epithelium-specific 65 kDa protein | Retinoid isomerohydrolase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60946.29
Organism:
Homo sapiens (Human)
Description:
Q16518
Residue:
533
Sequence:
MSIQVEHPAGGYKKLFETVEELSSPLTAHVTGRIPLWLTGSLLRCGPGLFEVGSEPFYHLFDGQALLHKFDFKEGHVTYHRRFIRTDAYVRAMTEKRIVITEFGTCAFPDPCKNIFSRFFSYFRGVEVTDNALVNVYPVGEDYYACTETNFITKINPETLETIKQVDLCNYVSVNGATAHPHIENDGTVYNIGNCFGKNFSIAYNIVKIPPLQADKEDPISKSEIVVQFPCSDRFKPSYVHSFGLTPNYIVFVETPVKINLFKFLSSWSLWGANYMDCFESNETMGVWLHIADKKRKKYLNNKYRTSPFNLFHHINTYEDNGFLIVDLCCWKGFEFVYNYLYLANLRENWEEVKKNARKAPQPEVRRYVLPLNIDKADTGKNLVTLPNTTATAILCSDETIWLEPEVLFSGPRQAFEFPQINYQKYCGKPYTYAYGLGLNHFVPDRLCKLNVKTKETWVWQEPDSYPSEPIFVSHPDALEEDDGVVLSVVVSPGAGQKPAYLLILNAKDLSEVARAEVEINIPVTFHGLFKKS
  
Inhibitor
Name:
BDBM323477
Synonyms:
3-Amino-1-(3-(4-(Benzyloxy)Butoxy)Phenyl)Propan-1-Ol | US10188615, Example 114 | US10639286, Example 114
Type:
Small organic molecule
Emp. Form.:
C20H27NO3
Mol. Mass.:
329.4333
SMILES:
NCCC(O)c1cccc(OCCCCOCc2ccccc2)c1
Structure:
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