Target
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Ligand
BDBM50396483
Substrate
n/a
Meas. Tech.
Raf IC50 Assay
Temperature
298.15±n/a K
IC50
31000±n/a nM
Comments
extracted
Citation
 Zhou, CZhang, G Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors US Patent  US9670203 Publication Date 6/6/2017 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase [306-648,Y340D,Y341D]
Synonyms:
C-Raf (Y340D/Y341D) | RAF | RAF1 | RAF1_HUMAN
Type:
n/a
Mol. Mass.:
38958.87
Organism:
Homo sapiens (Human)
Description:
PV3805, from Invitrogen
Residue:
343
Sequence:
SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSDDWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM50396483
Synonyms:
PLX-4032 | RG 7204 | Ro 5185426 | US10570155, Vemurafenib | US11332479, Compound Vemurafenib | US11492357, Control | US9388165, Reference, Vemurafenib (PLX-4032) | USRE47451, PLX-4032, Roche | VEMURAFENIB
Type:
Small organic molecule
Emp. Form.:
C23H18ClF2N3O3S
Mol. Mass.:
489.922
SMILES:
CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(cc23)-c2ccc(Cl)cc2)c1F
Structure:
Search PDB for entries with ligand similarity: