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Target
5'-AMP-activated protein kinase catalytic subunit alpha-2
Ligand
BDBM327862
Substrate
n/a
Meas. Tech.
Enzyme-Linked Immunosorbent Assay
EC50
<500±n/a nM
Citation
 Irving, M; Shaw, S AMPK-activating heterocyclic compounds and methods for using the same US Patent  US9663496 Publication Date 5/30/2017 
Target
Name:
5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms:
AAPK2_HUMAN | ACACA kinase | AMP-activated protein kinase, alpha-2 subunit | AMPK | AMPK subunit alpha-2 | AMPK-alpha2 | AMPK2 | Acetyl-CoA carboxylase kinase | Hydroxymethylglutaryl-CoA reductase kinase | PRKAA2
Type:
Enzyme
Mol. Mass.:
62331.02
Organism:
Homo sapiens (Human)
Description:
P54646
Residue:
552
Sequence:
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKFECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIPPGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVYRAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQRSGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFFEMCASLITTLAR
  
Inhibitor
Name:
BDBM327862
Synonyms:
N-(4-(4- cyanobenzyl)piperadin- 4-yl)-6-(4-(4- fluorobenzyl)piperizine- 1-carbonyl)picolinamide | US10377742, Compound 1 | US9663496, Compound 1
Type:
Small organic molecule
Emp. Form.:
C31H33FN6O2
Mol. Mass.:
540.6311
SMILES:
Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(cn2)C(=O)NC2CCN(Cc3ccc(cc3)C#N)CC2)cc1
Structure:
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