Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM13061
Substrate
BDBM11326
Meas. Tech.
Carbonic Anhydrase Inhibition Assay
pH
7.8±n/a
Temperature
293.15±n/a K
IC50
>1000±n/a nM
Citation
Lloyd, MD; Thiyagarajan, N; Ho, YT; Woo, LW; Sutcliffe, OB; Purohit, A; Reed, MJ; Acharya, KR; Potter, BV First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors. Biochemistry 44:6858-66 (2005) [PubMed] Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Inhibitor
Name:
BDBM13061
Synonyms:
4,4 -(1H-1,2,4-triazol-1-ylmethanediyl)dibenzonitrile | 4-[(4-cyanophenyl)(1H-1,2,4-triazol-1-yl)methyl]benzonitrile | CHEMBL1444 | Letrozole
Type:
Small organic molecule
Emp. Form.:
C17H11N5
Mol. Mass.:
285.3027
SMILES:
N#Cc1ccc(cc1)C(c1ccc(cc1)C#N)n1cncn1