Target
Tyrosine-protein kinase Mer
Ligand
BDBM336419
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<10±n/a nM
Citation
 Wang, XLiu, JYang, CZhang, WFrye, SKireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent  US9744172 Publication Date 8/29/2017 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM336419
Synonyms:
US9744172, Compound UNC1066A
Type:
Small organic molecule
Emp. Form.:
C24H32N6O3S
Mol. Mass.:
484.614
SMILES:
CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CC1 |r,wD:15.15,(-6.94,-3.57,;-5.61,-2.8,;-4.27,-3.57,;-2.94,-2.8,;-1.61,-3.57,;-.27,-2.8,;-.27,-1.26,;1.06,-.49,;2.39,-1.26,;3.86,-.79,;4.76,-2.03,;3.86,-3.28,;4.26,-4.77,;5.75,-5.16,;6.14,-6.65,;5.05,-7.74,;5.45,-9.23,;3.57,-7.34,;3.17,-5.85,;2.39,-2.8,;1.06,-3.57,;4.26,.7,;5.75,1.1,;6.14,2.59,;5.05,3.68,;3.57,3.28,;3.17,1.79,;5.45,5.16,;3.97,5.56,;6.94,4.77,;5.85,6.65,;4.76,7.74,;4.36,9.23,;3.28,8.14,)|
Structure:
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