Target
Tyrosine-protein kinase Mer
Ligand
BDBM336422
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<10±n/a nM
Citation
 Wang, XLiu, JYang, CZhang, WFrye, SKireev, D Pyrazolopyrimidine compounds for the treatment of cancer US Patent  US9744172 Publication Date 8/29/2017 
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM336422
Synonyms:
US9744172, Compound UNC1179A
Type:
Small organic molecule
Emp. Form.:
C24H33N7O
Mol. Mass.:
435.5651
SMILES:
CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)NC |r,wD:16.16,(-8.68,-3.65,;-7.35,-2.88,;-6.01,-3.65,;-4.68,-2.88,;-3.34,-3.65,;-2.01,-2.88,;-2.01,-1.34,;-.68,-.57,;.66,-1.34,;2.12,-.86,;3.03,-2.11,;2.12,-3.35,;2.52,-4.84,;4.06,-4.84,;4.83,-3.51,;6.37,-3.51,;7.14,-4.84,;8.68,-4.84,;6.37,-6.18,;4.83,-6.18,;.66,-2.88,;-.68,-3.65,;2.52,.62,;4.01,1.02,;4.41,2.51,;3.32,3.6,;1.83,3.2,;1.43,1.71,;3.72,5.09,;2.63,6.18,;5.2,5.49,;6.29,4.4,)|
Structure:
Search PDB for entries with ligand similarity: