Reaction Details Report a problem with these data
Target
Actin [R183K]
Ligand
BDBM65506
Substrate
n/a
Meas. Tech.
Liquid growth assay
Temperature
303.15±0 K
IC50
380±0.0 nM
Citation
 Filipuzzi, I; Thomas, JR; Pries, V; Estoppey, D; Salcius, M; Studer, C; Schirle, M; Hoepfner, D Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide. ACS Chem Biol 12:2264-2269 (2017) [PubMed]  Article 
Target
Name:
Actin [R183K]
Synonyms:
ABY1 | ACT1 | ACT1 (R183K) | ACT_YEAST | Actin (R183K) | END7
Type:
Protein
Mol. Mass.:
41655.11
Organism:
Baker's yeast
Description:
P60010 (R183K)
Residue:
375
Sequence:
MDSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAGKDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPERKYSVWIGGSILASLTTFQQMWISKQEYDESGPSIVHHKCF
  
Inhibitor
Name:
BDBM65506
Synonyms:
CHEBI:80062 | Chivosazole F | SCHEMBL1889389
Type:
Small organic molecule
Emp. Form.:
C41H57NO8
Mol. Mass.:
691.8932
SMILES:
COC1CC(O)\C=C\C=C\C=C/C(C)C(OC(=O)\C=C/C=C/C=C\C(\C)=C\C(C)C(O)\C=C/C=C/c2coc(n2)C1C)C(C)C(O)CC(C)O |c:10,18,22,31,t:6,8,20,25,33|
Structure:
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