Target
Actin [R335K]
Ligand
BDBM65516
Substrate
n/a
Meas. Tech.
Liquid growth assay
Temperature
303.15±0 K
IC50
15100±0.0 nM
Citation
 Filipuzzi, IThomas, JRPries, VEstoppey, DSalcius, MStuder, CSchirle, MHoepfner, D Direct Interaction of Chivosazole F with Actin Elicits Cell Responses Similar to Latrunculin A but Distinct from Chondramide. ACS Chem Biol 12:2264-2269 (2017) [PubMed]  Article 
Target
Name:
Actin [R335K]
Synonyms:
ABY1 | ACT1 | ACT1 (R335K) | ACT_YEAST | Actin | END7
Type:
Protein
Mol. Mass.:
41655.11
Organism:
Baker's yeast
Description:
P60010 (R335K)
Residue:
375
Sequence:
MDSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILTLRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAGRDLTDYLMKILSERGYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEALFHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMKVKIIAPPEKKYSVWIGGSILASLTTFQQMWISKQEYDESGPSIVHHKCF
  
Inhibitor
Name:
BDBM65516
Synonyms:
CHEBI:84382 | CHEMBL2426321 | Chondramide C
Type:
Small organic molecule
Emp. Form.:
C35H44N4O6
Mol. Mass.:
616.7471
SMILES:
C[C@H]1OC(=O)C[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C\C(C)=C\[C@H]1C)c1ccc(O)cc1 |t:36|
Structure:
Search PDB for entries with ligand similarity: