Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM14827
Substrate
Cdc25C peptide substrate
Meas. Tech.
Chk1 Enzymatic Assay
pH
7.4±n/a
Temperature
295.15±n/a K
IC50
5±n/a nM
Citation
 Wang, GTLi, GMantei, RAChen, ZKovar, PGu, WXiao, ZZhang, HSham, HLSowin, TRosenberg, SHLin, NH 1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities. J Med Chem 48:3118-21 (2005) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM14827
Synonyms:
(+/-)1-[5-Chloro-2-(tetrahydro-pyran-4-yloxy)-phenyl]-3-(5-cyano-pyrazin-2-yl)-urea | 3-[5-chloro-2-(oxan-4-yloxy)phenyl]-1-(5-cyanopyrazin-2-yl)urea | urea-based inhibitor 2b
Type:
Small organic molecule
Emp. Form.:
C17H16ClN5O3
Mol. Mass.:
373.794
SMILES:
Clc1ccc(OC2CCOCC2)c(NC(=O)Nc2cnc(cn2)C#N)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Cdc25C peptide substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
2519.88
Organism:
n/a
Description:
Cdc25c peptide substrate contained a sequence of amino acid residues 204-225 of human phosphatase Cdc25C.
Residue:
22
Sequence:
AKVSRSGLYRSPSMPENLNRPR