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Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM347437
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
2.50±n/a nM
Citation
 Markowitz, S; Willson, JK; Posner, B; Ready, J; Antczak, M; Zhang, Y; Desai, A; Gerson, S; Greenlee, W Compositions and methods of modulating short-chain dehydrogenase activity US Patent  US9789116 Publication Date 10/17/2017 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM347437
Synonyms:
US10869871, ID # SW209508 | US20230285402, ID # SW209508 | US9789116, SW209508
Type:
Small organic molecule
Emp. Form.:
C24H24N4O2S3
Mol. Mass.:
496.668
SMILES:
CCCCS(=O)c1sc2nc(cc(-c3cccc(c3)C(=O)NCC=C)c2c1N)-c1nccs1
Structure:
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