Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Ligand
BDBM347359
Substrate
n/a
Meas. Tech.
In Vitro Assay
IC50
0.760±n/a nM
Citation
 Markowitz, SWillson, JKPosner, BAReady, JZhang, YTai, HAntczak, MGerson, SBae, KYang, SYDesai, A Compositions and methods of modulating 15-PGDH activity US Patent  US9790233 Publication Date 10/17/2017 
Target
Name:
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Synonyms:
15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD+] | HPGD | PGDH1 | PGDH_HUMAN | Prostaglandin dehydrogenase 1 (15-PGDH) | SDR36C1
Type:
Enzyme
Mol. Mass.:
28974.46
Organism:
Homo sapiens (Human)
Description:
P15428
Residue:
266
Sequence:
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
  
Inhibitor
Name:
BDBM347359
Synonyms:
US10301320, ID SW033291 | US10869871, ID # SW033291 | US20230285402, ID # SW206976 | US9789116, SW033291
Type:
Small organic molecule
Emp. Form.:
C21H20N2OS3
Mol. Mass.:
412.591
SMILES:
CCCCS(=O)c1sc2nc(cc(-c3ccccc3)c2c1N)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: