Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM275094
Substrate
n/a
Meas. Tech.
Inhibitory Test of TNAP Activity
IC50
2.20±n/a nM
Citation
 Miyazaki, SYamamoto, YSuzuki, KInui, MIzumi, MSoma, KPinkerton, AShinozaki, T Pyridine compounds US Patent  US10221195 Publication Date 3/5/2019 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM275094
Synonyms:
US10221195, Example 41 | US9879032, Example 36
Type:
Small organic molecule
Emp. Form.:
C17H16FN3O5S
Mol. Mass.:
393.389
SMILES:
COc1ccc(F)cc1S(=O)(=O)Nc1cnc2OCC3(CC3)NC(=O)c2c1
Structure:
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