Target
3-phosphoinositide-dependent protein kinase 1 [51-360]
Ligand
BDBM366120
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
<500±n/a nM
Citation
 Lind, KECao, KLin, EYNguyen, TBTangonan, BTErlanson, DAGuckian, KSimmons, RLLee, WSun, LHansen, SPathan, NZhang, L Methods of treatment using pyridinonyl PDK1 inhibitors US Patent  US9873693 Publication Date 1/23/2018 
Target
Name:
3-phosphoinositide-dependent protein kinase 1 [51-360]
Synonyms:
3-phosphoinositide-dependent protein kinase 1 (PDK1) | PDK1 | PDPK1 | PDPK1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35373.34
Organism:
Homo sapiens (Human)
Description:
(aa 51-360)
Residue:
310
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTPPKLTA
  
Inhibitor
Name:
BDBM366120
Synonyms:
US9873693, Compound 246 | US9873693, Compound 43
Type:
Small organic molecule
Emp. Form.:
C28H20F2N8O2
Mol. Mass.:
538.5076
SMILES:
Fc1ccc(Cn2cccc(C(=O)NCc3cccc(c3)-c3c[nH]c4ncc(cc34)-c3nnn[nH]3)c2=O)cc1F
Structure:
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