Reaction Details Report a problem with these data
Target
Galectin-3
Ligand
BDBM21541
Substrate
BDBM21520
Meas. Tech.
Fluorescence Polarization Assay
pH
7.2±n/a
Temperature
297.15±n/a K
Kd
5900000±1400000 nM
Citation
Oberg, CT; Leffler, H; Nilsson, UJ Arginine binding motifs: design and synthesis of galactose-derived arginine tweezers as galectin-3 inhibitors. J Med Chem 51:2297-301 (2008) [PubMed] Article
More Info.:
Target
Name:
Galectin-3
Synonyms:
LEG3_HUMAN | LGALS3 | MAC2
Type:
Enzyme
Mol. Mass.:
26156.54
Organism:
Homo sapiens (Human)
Description:
P17931
Residue:
250
Sequence:
MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI
Inhibitor
Name:
BDBM21541
Synonyms:
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(methylsulfanyl)oxane-3,4,5-triol | Galactose-Derived Compound 19
Type:
Small organic molecule
Emp. Form.:
C7H14O5S
Mol. Mass.:
210.248
SMILES:
CS[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O