Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM23165
Substrate
BDBM22202
Meas. Tech.
[32P] S1P Binding Assay
pH
7.5±n/a
Temperature
277.15±n/a K
Ki
2.1±0.12 nM
Citation
 Kiuchi, MAdachi, KTomatsu, AChino, MTakeda, STanaka, YMaeda, YSato, NMitsutomi, NSugahara, KChiba, K Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate. Bioorg Med Chem 13:425-32 (2005) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM23165
Synonyms:
CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy]phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C19H34NO5P
Mol. Mass.:
387.4507
SMILES:
CCCCCCCCc1ccc(CC[C@](N)(CO)COP(O)(O)=O)cc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM22202
Synonyms:
S1P | [32P]S1P | [33P]S1P | sphingosine-1-phosphate | sphingosine-1-phosphate, 32P labeled | sphingosine-1-phosphate, 33P labeled | {[(4Z)-2-amino-3-hydroxyoctadec-4-en-1-yl]oxy}phosphonic acid
Type:
radiolabeled ligand
Emp. Form.:
C18H38NO5P
Mol. Mass.:
379.4718
SMILES:
CCCCCCCCCCCCC\C=C/C(O)C(N)COP(O)(O)=O
Structure:
Search PDB for entries with ligand similarity: