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Target
L-lactate dehydrogenase
Ligand
BDBM23225
Substrate
BDBM19473
Meas. Tech.
Lactate Dehydrogenase Inhibition Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
>241000±n/a nM
Citation
 Choi, SR; Pradhan, A; Hammond, NL; Chittiboyina, AG; Tekwani, BL; Avery, MA Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors. J Med Chem 50:3841-50 (2007) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase
Synonyms:
L-lactate dehydrogenase | LDH_PLAFD | Lactate Dehydrogenase | pfLDH
Type:
Oxidoreductase
Mol. Mass.:
34111.90
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
316
Sequence:
MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA
  
Inhibitor
Name:
BDBM23225
Synonyms:
7-{2-[4-(formamidoformic acid)phenyl]ethoxy}-5-hydroxy-4-oxo-4H-chromene-2-carboxylic acid | Oxamic acid derivative, 2
Type:
Small organic molecule
Emp. Form.:
C20H15NO9
Mol. Mass.:
413.3344
SMILES:
OC(=O)C(=O)Nc1ccc(CCOc2cc(O)c3c(c2)oc(cc3=O)C(O)=O)cc1
Structure:
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Substrate
Name:
BDBM19473
Synonyms:
2-Oxopropanoate | 2-oxopropanoic acid | Pyruvate
Type:
Small organic molecule
Emp. Form.:
C3H4O3
Mol. Mass.:
88.0621
SMILES:
CC(=O)C(O)=O
Structure:
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