Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase
Ligand
BDBM23256
Substrate
BDBM23233
Meas. Tech.
Lactate Dehydrogenase Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
>100000±n/a nM
Citation
Cameron, A; Read, J; Tranter, R; Winter, VJ; Sessions, RB; Brady, RL; Vivas, L; Easton, A; Kendrick, H; Croft, SL; Barros, D; Lavandera, JL; Martin, JJ; Risco, F; García-Ochoa, S; Gamo, FJ; Sanz, L; Leon, L; Ruiz, JR; Gabarró, R; Mallo, A; Gómez de las Heras, F Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity. J Biol Chem 279:31429-39 (2004) [PubMed] Article
Target
Name:
L-lactate dehydrogenase
Synonyms:
L-lactate dehydrogenase | LDH_PLAFD | Lactate Dehydrogenase | pfLDH
Type:
Oxidoreductase
Mol. Mass.:
34111.90
Organism:
Plasmodium falciparum
Description:
n/a
Residue:
316
Sequence:
MAPKAKIVLVGSGMIGGVMATLIVQKNLGDVVLFDIVKNMPHGKALDTSHTNVMAYSNCKVSGSNTYDDLAGADVVIVTAGFTKAPGKSDKEWNRDDLLPLNNKIMIEIGGHIKKNCPNAFIIVVTNPVDVMVQLLHQHSGVPKNKIIGLGGVLDTSRLKYYISQKLNVCPRDVNAHIVGAHGNKMVLLKRYITVGGIPLQEFINNKLISDAELEAIFDRTVNTALEIVNLHASPYVAPAAAIIEMAESYLKDLKKVLICSTLLEGQYGHSDIFGGTPVVLGANGVEQVIELQLNSEEKAKFDEAIAETKRMKALA
Inhibitor
Name:
BDBM23256
Synonyms:
1-benzyl-4-hydroxy-1H-1,2,3-triazole-5-carboxylic acid | Triazole, TRZ3
Type:
Small organic molecule
Emp. Form.:
C10H9N3O3
Mol. Mass.:
219.1968
SMILES:
OC(=O)c1c(O)nnn1Cc1ccccc1