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Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Ligand
BDBM261606
Substrate
n/a
Meas. Tech.
ACMSD1 Inhibition Assay
IC50
5.00±n/a nM
Citation
 Pellicciari, R; Auwerx, J; Raffaelli, N Inhibitors of α-amino-β-carboxymuconic acid semialdehyde decarboxylase US Patent  US9708272 Publication Date 7/18/2017 
Target
Name:
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Synonyms:
ACMSD | ACMSD_HUMAN | Picolinate carboxylase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38037.38
Organism:
Homo sapiens (Human)
Description:
Q8TDX5
Residue:
336
Sequence:
MKIDIHSHILPKEWPDLKKRFGYGGWVQLQHHSKGEAKLLKDGKVFRVVRENCWDPEVRIREMDQKGVTVQALSTVPVMFSYWAKPEDTLNLCQLLNNDLASTVVSYPRRFVGLGTLPMQAPELAVKEMERCVKELGFPGVQIGTHVNEWDLNAQELFPVYAAAERLKCSLFVHPWDMQMDGRMAKYWLPWLVGMPAETTIAICSMIMGGVFEKFPKLKVCFAHGGGAFPFTVGRISHGFSMRPDLCAQDNPMNPKKYLGSFYTDALVHDPLSLKLLTDVIGKDKVILGTDYPFPLGELEPGKLIESMEEFDEETKNKLKAGNALAFLGLERKQFE
  
Inhibitor
Name:
BDBM261606
Synonyms:
US10513499, Compound 17 | US11254644, Compound 17 | US9708272, 17
Type:
Small organic molecule
Emp. Form.:
C17H11N7OS2
Mol. Mass.:
393.446
SMILES:
O=c1[nH]c(SCc2cccc(c2)-c2nn[nH]n2)nc(-c2cccs2)c1C#N
Structure:
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