Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM377137
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
5500±n/a nM
Citation
 Zablocki, JA; Elzein, EO; Palle, VP; Belardinelli, L 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists US Patent  USRE47351 Publication Date 4/16/2019 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_CAVPO | ADENOSINE A2 | ADORA2A | Adenosine A2a receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44955.08
Organism:
GUINEA PIG
Description:
ADENOSINE A2 0 GUINEA PIG::P46616
Residue:
409
Sequence:
MSSSVYITVELVIAVLAILGNVLVCWAVWINSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLTITIDRYIAIRIPLRYNGLVTCTRAKGIIAICWVLSFAIGLTPMLGWNNCSQPKGDKNHSESCDEGQVTCLFEDVVPMNYMVYYNFFAFVLVPLLLMLGIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHPAKSLAIIVGLFALCCLPLNIINCFTFFCPECDHAPPWLMYLTIILSHGNSVVNPLIYAYRIREFRQTFRKIIRSHILRRRELFKAGGTSARASAAHSPEGEQVSLRLNGHPPGVWANGSALRPEQRPNGYVLGLVSGRSAQRSHGDASLSDVELLSHEHKGTCPESPSLEDPPAHGGAGVS
  
Inhibitor
Name:
BDBM377137
Synonyms:
(4S,2R,3R,5R)-2-{6-Amino2-[4-(4-methylphenyl)pyrazolyl]purin-9-yl}-5-(hydroxymethyl)oxolane-3,4-diol | USRE47351, Compound 15
Type:
Small organic molecule
Emp. Form.:
C20H21N7O4
Mol. Mass.:
423.4252
SMILES:
Cc1ccc(cc1)-c1cnn(c1)-c1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 |r|
Structure:
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