Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM377144
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
505±n/a nM
Citation
 Zablocki, JA; Elzein, EO; Palle, VP; Belardinelli, L 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists US Patent  USRE47351 Publication Date 4/16/2019 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_CAVPO | ADENOSINE A2 | ADORA2A | Adenosine A2a receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44955.08
Organism:
GUINEA PIG
Description:
ADENOSINE A2 0 GUINEA PIG::P46616
Residue:
409
Sequence:
MSSSVYITVELVIAVLAILGNVLVCWAVWINSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLTITIDRYIAIRIPLRYNGLVTCTRAKGIIAICWVLSFAIGLTPMLGWNNCSQPKGDKNHSESCDEGQVTCLFEDVVPMNYMVYYNFFAFVLVPLLLMLGIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHPAKSLAIIVGLFALCCLPLNIINCFTFFCPECDHAPPWLMYLTIILSHGNSVVNPLIYAYRIREFRQTFRKIIRSHILRRRELFKAGGTSARASAAHSPEGEQVSLRLNGHPPGVWANGSALRPEQRPNGYVLGLVSGRSAQRSHGDASLSDVELLSHEHKGTCPESPSLEDPPAHGGAGVS
  
Inhibitor
Name:
BDBM377144
Synonyms:
(1-{9-[(4S,2R,3R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-aminopurin-2yl}pyrazol-4yl)-N-[(4- chlorophenyl)methyl]carboxamide | USRE47351, Compound 22
Type:
Small organic molecule
Emp. Form.:
C21H21ClN8O5
Mol. Mass.:
500.895
SMILES:
Nc1nc(nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@H]1O)-n1cc(cn1)C(=O)NCc1ccc(Cl)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: