Reaction Details Report a problem with these data
Target
Cytosol aminopeptidase
Ligand
BDBM23980
Substrate
BDBM23972
Meas. Tech.
Enzyme Inhibition Assay
pH
8±n/a
Temperature
303.15±n/a K
IC50
>100000±n/a nM
Citation
Albrecht, S; Defoin, A; Salomon, E; Tarnus, C; Wetterholm, A; Haeggström, JZ Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors. Bioorg Med Chem 14:7241-57 (2006) [PubMed] Article
More Info.:
Target
Name:
Cytosol aminopeptidase
Synonyms:
AMPL_BOVIN | LAP | LAP3 | LAPc | Leucine Aminopeptidase | Leucyl aminopeptidase
Type:
Homohexamer
Mol. Mass.:
56288.28
Organism:
Bos taurus (bovine)
Description:
Bovine kidney LAPc was purchased from Sigma Chemical Co.
Residue:
519
Sequence:
MFLLPLPAAARVAVRHLSVKRLWAPGPAAADMTKGLVLGIYSKEKEEDEPQFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKENIRAAVAAGCRQIQDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHGSEDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPLVFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMAGRPTRTLIEFLFRFSQDSA
Inhibitor
Name:
BDBM23980
Synonyms:
(3Z)-3-{[(5-phenylpentyl)oxy]imino}-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride | Tetralone-oxime derivative, 2g
Type:
Small organic molecule
Emp. Form.:
C21H26N2O
Mol. Mass.:
322.4439
SMILES:
NC1Cc2ccccc2C\C1=N\OCCCCCc1ccccc1