Target
Cytosol aminopeptidase
Ligand
BDBM23989
Substrate
BDBM23972
Meas. Tech.
Enzyme Inhibition Assay
pH
8±n/a
Temperature
303.15±n/a K
IC50
>1000000±n/a nM
Citation
 Albrecht, SDefoin, ASalomon, ETarnus, CWetterholm, AHaeggström, JZ Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors. Bioorg Med Chem 14:7241-57 (2006) [PubMed]  Article 
Target
Name:
Cytosol aminopeptidase
Synonyms:
AMPL_BOVIN | LAP | LAP3 | LAPc | Leucine Aminopeptidase | Leucyl aminopeptidase
Type:
Homohexamer
Mol. Mass.:
56288.28
Organism:
Bos taurus (bovine)
Description:
Bovine kidney LAPc was purchased from Sigma Chemical Co.
Residue:
519
Sequence:
MFLLPLPAAARVAVRHLSVKRLWAPGPAAADMTKGLVLGIYSKEKEEDEPQFTSAGENFNKLVSGKLREILNISGPPLKAGKTRTFYGLHEDFPSVVVVGLGKKTAGIDEQENWHEGKENIRAAVAAGCRQIQDLEIPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKRKVVVSAKLHGSEDQEAWQRGVLFASGQNLARRLMETPANEMTPTKFAEIVEENLKSASIKTDVFIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYKGSPNASEPPLVFVGKGITFDSGGISIKAAANMDLMRADMGGAATICSAIVSAAKLDLPINIVGLAPLCENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDIALGSGATGVFTNSSWLWNKLFEASIETGDRVWRMPLFEHYTRQVIDCQLADVNNIGKYRSAGACTAAAFLKEFVTHPKWAHLDIAGVMTNKDEVPYLRKGMAGRPTRTLIEFLFRFSQDSA
  
Inhibitor
Name:
BDBM23989
Synonyms:
1,2,3,4-tetrahydronaphthalen-2-one | CHEMBL191664 | dihydro-naphthalenone, 4e | dihydronaphthalenone
Type:
Small organic molecule
Emp. Form.:
C10H10O
Mol. Mass.:
146.1858
SMILES:
O=C1CCc2ccccc2C1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM23972
Synonyms:
(2S)-2-amino-4-methyl-N-(4-nitrophenyl)pentanamide | L-Leucine-p-nitroanilide | L-Leucine-para-nitroanilide
Type:
n/a
Emp. Form.:
C12H17N3O3
Mol. Mass.:
251.2817
SMILES:
CC(C)C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O |r|
Structure:
Search PDB for entries with ligand similarity: