Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 7
Ligand
BDBM352200
Substrate
n/a
Meas. Tech.
Radiolabel Binding Studies for Serotonin 5-HT7 Receptors, Method 2
IC50
10.00±n/a nM
Citation
 Canney, DJ; Blass, BE; Gao, R; Abou-Gharbia, M 5-hydroxytryptamine receptor 7 activity modulators and their method of use US Patent  US10287274 Publication Date 5/14/2019
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM352200
Synonyms:
US10239868, Entry 4 | US10287274, Entry 4 | US10676464, Entry 4 | US9802924, Entry 4
Type:
Small organic molecule
Emp. Form.:
C21H32N2O2
Mol. Mass.:
344.491
SMILES:
CCC1(CC)CC(CCN2CCN(CC2)c2ccc(C)cc2)OC1=O
Structure:
Search PDB for entries with ligand similarity: