Target
Acidic mammalian chitinase
Ligand
BDBM388687
Substrate
n/a
Meas. Tech.
Human AMCase Activity Assay
IC50
<100±n/a nM
Citation
 Mazur, MKoralewski, RBorek, BOlejniczak, SCzestkowski, WJPiotrowicz, MCOlczak, JPGolebiowski, AABartoszewicz, AMaziarz, EKowalski, M Substituted amino triazoles useful as human chitinase inhibitors US Patent  US9944624 Publication Date 4/17/2018 
Target
Name:
Acidic mammalian chitinase
Synonyms:
AMCase | Acidic mammalian chitinase (AMCase) | CHIA | CHIA_HUMAN | Lung-specific protein TSA1902
Type:
Protein
Mol. Mass.:
52266.66
Organism:
Homo sapiens (Human)
Description:
Q9BZP6
Residue:
476
Sequence:
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
  
Inhibitor
Name:
BDBM388687
Synonyms:
5-(4-((3S,8aS)-3-(4-chlorobenzyl)hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)piperidin-1-yl)-4H-1,2,4-triazol-3-amine | US10538508, Example 49 | US9944624, Ex. 49
Type:
Small organic molecule
Emp. Form.:
C21H30ClN7
Mol. Mass.:
415.963
SMILES:
Nc1nnc([nH]1)N1CCC(CC1)N1C[C@@H]2CCCN2CC1Cc1ccc(Cl)cc1 |r|
Structure:
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