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Target
Mu-type opioid receptor
Ligand
BDBM462395
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
Ki
57.0±n/a nM
Citation
 Shoichet, BK; Levit, A; Manglik, A; Kobilka, B; Gmeiner, P; Hübner, H; Dengler, DG Mu opioid receptor modulators US Patent  US10780078 Publication Date 9/22/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM462395
Synonyms:
US10780078, Compound DD 272B
Type:
Small organic molecule
Emp. Form.:
C21H29N3O2S
Mol. Mass.:
387.539
SMILES:
C[C@@H](Cc1ccsc1)NC(=O)NC[C@@]1(CCc2cc(O)ccc2C1)N(C)C
Structure:
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